{"product_id":"mots-c-research-peptide","title":"MOTC","description":"\u003cp data-path-to-node=\"7\"\u003e\u003cstrong\u003eMOTS-c\u003c\/strong\u003e identified in 2015, acts as a mitochondrial-encoded signaling molecule that links mitochondrial activity to systemic metabolism. By primarily targeting skeletal muscle, it helps maintain cellular energy homeostasis through the activation of the AMPK (AMP-activated protein kinase) pathway.\u003c\/p\u003e\n\u003ch3 data-path-to-node=\"8\"\u003eProperties of MOTS-c\u003c\/h3\u003e\n\u003cul data-path-to-node=\"9\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"9,0,0\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"9,0,0\"\u003ePeptide Sequence:\u003c\/b\u003e Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"9,1,0\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"9,1,0\"\u003eChemical Formula:\u003c\/b\u003e C101H152N28O22S2\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"9,2,0\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"9,2,0\"\u003eMolecular Mass:\u003c\/b\u003e 2,174.6 g\/mol\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"9,3,0\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"9,3,0\"\u003eCAS Number:\u003c\/b\u003e 1627580-64-6\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"9,4,0\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"9,4,0\"\u003ePubChem:\u003c\/b\u003e 255386757\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"9,5,0\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"9,5,0\"\u003eVial Size:\u003c\/b\u003e 3ml\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3 data-path-to-node=\"10\"\u003eDisclaimer\u003c\/h3\u003e\n\u003cp id=\"p-rc_0e2523fd72e96fa2-26\" data-path-to-node=\"11\"\u003e\u003cspan class=\"citation-108\"\u003e\u003c\/span\u003e\u003cspan class=\"citation-108 citation-109\"\u003e\u003c\/span\u003e\u003cspan class=\"citation-108 citation-109 citation-110 citation-end-110\"\u003eThis content is provided strictly for research purposes and does not constitute an endorsement or recommendation for the non-laboratory application or improper handling of peptides designed for research. The information, including discussions about specific peptides and their researched benefi\u003csup data-turn-source-index=\"1\" class=\"superscript\"\u003e\u003c!----\u003e\u003c\/sup\u003e\u003c\/span\u003e\u003cspan class=\"citation-108 citation-109\"\u003ets, is presented for informational purposes only \u003c\/span\u003e\u003cspan class=\"citation-106 citation-108 citation-109\"\u003e\u003c\/span\u003e\u003cspan class=\"citation-106 citation-107 citation-108 citation-109 citation-end-109\"\u003eand must not be construed as health, clinical, or legal guidance, nor an encourag\u003csup data-turn-source-index=\"2\" class=\"superscript\"\u003e\u003c!----\u003e\u003c\/sup\u003e\u003c\/span\u003e\u003cspan class=\"citation-106 citation-107 citation-108 citation-end-108\"\u003eement for non-research use in humans. \u003csup data-turn-source-index=\"3\" class=\"superscript\"\u003e\u003c!----\u003e\u003c\/sup\u003e\u003c\/span\u003e\u003cspan class=\"citation-106 citation-107\"\u003e\u003c\/span\u003e\u003cspan class=\"citation-105 citation-106 citation-107 citation-end-107\"\u003ePeptides described here are solely for use in structured scientific study by authorized individua\u003csup data-turn-source-index=\"4\" class=\"superscript\"\u003e\u003c!----\u003e\u003c\/sup\u003e\u003c\/span\u003e\u003cspan class=\"citation-105 citation-106 citation-end-106\"\u003els. We advise con\u003csup data-turn-source-index=\"5\" class=\"superscript\"\u003e\u003c!----\u003e\u003c\/sup\u003e\u003c\/span\u003e\u003cspan class=\"citation-105 citation-end-105\"\u003esulting with research experts, medical practitioners, or legal counsel prior to any decisions about obtaining or utilizing these peptid\u003csup data-turn-source-index=\"6\" class=\"superscript\"\u003e\u003c!----\u003e\u003c\/sup\u003e\u003c\/span\u003ees. \u003cspan class=\"citation-104 citation-end-104\"\u003eThe expectation of responsible, ethical utilization of this information for legitimate investigative and scholarly objectives is paramount. This notice is dynamic and governs all provided content on research \u003csup data-turn-source-index=\"7\" class=\"superscript\"\u003e\u003c!----\u003e\u003c\/sup\u003e\u003c\/span\u003epeptides.\u003c\/p\u003e\n\u003cdiv class=\"source-inline-chip-container luminous-sources ng-star-inserted\"\u003e\n\u003ch3\u003eResearch\u003c\/h3\u003e\n\u003cp\u003e\u003cbr\u003eCurrent research indicates MOTS-c is a significant subject of study for metabolic and age-related conditions. While human clinical data is in the early stages, animal models have provided extensive insights into its mechanisms.\u003c\/p\u003e\n\u003cp\u003eMetabolic Regulation\u003cbr\u003eMOTS-c modulates nuclear gene expression by translocating to the nucleus under metabolic stress, interacting with transcription factors like NRF2 to influence glucose metabolism and antioxidant responses.¹ It activates the AMPK pathway, which enhances insulin sensitivity and energy dissipation, effectively preventing diet-induced obesity and metabolic dysfunction, particularly in postmenopausal models.²,³\u003c\/p\u003e\n\u003cp\u003eNeuroprotection and Cognitive Function\u003cbr\u003eThe peptide exhibits anti-inflammatory properties, suppressing the activation of astrocytes and microglia to reduce proinflammatory cytokines like IL-6, TNF-α, and COX-2.⁴ This neuroprotective effect has been linked to improved cognitive performance and memory consolidation in Alzheimer's disease and traumatic brain injury models.⁵ Additionally, MOTS-c supports brain function post-injury by enhancing lipid β-oxidation.⁴\u003c\/p\u003e\n\u003cp\u003eMuscle Homeostasis and Physical Decline\u003cbr\u003eMOTS-c regulates genes related to proteostasis and metabolism, helping myoblasts adapt to stress and preventing atrophy.⁶,⁷ By reducing myostatin—a negative regulator of muscle mass—it maintains muscle growth through the PTEN\/AKT\/FOXO1 signaling pathway.⁷ Its expression in human skeletal muscle during exercise suggests it plays a natural role in maintaining physical capacity throughout aging.⁶\u003c\/p\u003e\n\u003cp\u003eLongevity and Anti-Aging\u003cbr\u003eResearch positions MOTS-c as a prospective therapeutic for promoting longevity.⁸ Beyond its role in metabolic and physical health, specific genetic polymorphisms in the MOTS-c encoding region have been associated with exceptional human longevity, suggesting a possible biological basis for its anti-aging potential.⁹\u003c\/p\u003e\n\u003cp\u003eReferences\u003cbr\u003eKim, K., Son, J., Benayoun, B., \u0026amp; Lee, C. (2018). The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress.. Cell metabolism, 28 3, 516-524.e7 . https:\/\/doi.org\/10.1016\/j.cmet.2018.06.008.\u003c\/p\u003e\n\u003cp\u003eLu, H., Wei, M., Zhai, Y., Li, Q., Ye, Z., Wang, L., Luo, W., Chen, J., \u0026amp; Lu, Z. (2019). MOTS-c peptide regulates adipose homeostasis to prevent ovariectomy-induced metabolic dysfunction. Journal of Molecular Medicine, 97, 473 – 485. https:\/\/doi.org\/10.1007\/s00109-018-01738-w.\u003c\/p\u003e\n\u003cp\u003eLee, C., Zeng, J., Drew, B., Sallam, T., Martín-Montalvo, A., Wan, J., Kim, S., Mehta, H., Hevener, A., De Cabo, R., \u0026amp; Cohen, P. (2015). The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance.. Cell metabolism, 21 3, 443-54 . https:\/\/doi.org\/10.1016\/j.cmet.2015.02.009.\u003c\/p\u003e\n\u003cp\u003eLi, F., Jia, Y., Fang, J., Gong, L., Zhang, Y., Wei, S., Wu, L., \u0026amp; Jiang, P. (2024). Neuroprotective Mechanism of MOTS-c in TBI Mice: Insights from Integrated Transcriptomic and Metabolomic Analyses. Drug Design, Development and Therapy, 18, 2971 – 2987. https:\/\/doi.org\/10.2147\/DDDT.S460265.\u003c\/p\u003e\n\u003cp\u003eJiang, J., Chang, X., Nie, Y., Shen, Y., Liang, X., Peng, Y., \u0026amp; Chang, M. (2021). Peripheral Administration of a Cell-Penetrating MOTS-c Analogue Enhances Memory and Attenuates Aβ1-42- or LPS-Induced Memory Impairment through Inhibiting Neuroinflammation.. ACS chemical neuroscience. https:\/\/doi.org\/10.1021\/acschemneuro.0c00782.\u003c\/p\u003e\n\u003cp\u003eReynolds, J., Lai, R., Woodhead, J., Joly, J., Mitchell, C., Cameron-Smith, D., Lu, R., Cohen, P., Graham, N., Benayoun, B., Merry, T., \u0026amp; Lee, C. (2021). MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nature Communications. https:\/\/doi.org\/10.1038\/s41467-020-20790-0.\u003c\/p\u003e\n\u003cp\u003eKumagai, H., Coelho, A., Wan, J., Mehta, H., Yen, K., Huang, A., Zempo, H., Fuku, N., Maeda, S., Oliveira, P., Cohen, P., \u0026amp; Kim, S. (2021). MOTS-c reduces myostatin and muscle atrophy signaling.. American journal of physiology. Endocrinology and metabolism. https:\/\/doi.org\/10.1152\/ajpendo.00275.2020.\u003c\/p\u003e\n\u003cp\u003eMohtashami, Z., Singh, M., Salimiaghdam, N., Ozgul, M., \u0026amp; Kenney, M. (2022). MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related Diseases. International Journal of Molecular Sciences, 23. https:\/\/doi.org\/10.3390\/ijms231911991.\u003c\/p\u003e\n\u003cp\u003eFuku, N., Pareja-Galeano, H., Zempo, H., Alis, R., Arai, Y., Lucia, A., \u0026amp; Hirose, N. (2015). The mitochondrial‐derived peptide MOTS‐c: a player in exceptional longevity?. Aging Cell, 14, 921 – 923. https:\/\/doi.org\/10.1111\/acel.12389.\u003c\/p\u003e\n\u003cbr\u003e\n\u003c\/div\u003e\n\u003cp\u003e \u003c\/p\u003e","brand":"Metric Verify","offers":[{"title":"10 mg","offer_id":48615659536576,"sku":null,"price":39.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0767\/4475\/3344\/files\/MOTS-c_product_image_master_copy.png?v=1784010563","url":"https:\/\/metricverify.com\/products\/mots-c-research-peptide","provider":"Metric Verify","version":"1.0","type":"link"}