{"product_id":"melanotan-1-research-peptide","title":"MT1","description":"\u003cdiv class=\"source-inline-chip-container luminous-sources ng-star-inserted\"\u003e\n\u003cstrong\u003e\u003c\/strong\u003e\u003cbr\u003e\n\u003c\/div\u003e\n\u003cp data-path-to-node=\"1\"\u003e\u003cstrong\u003eMelanotan-1\u003c\/strong\u003e, also referred to as afamelanotide or melanotan-I, is a synthetic peptide hormone analog. Its primary activity involves binding to and activating melanocortin receptors, with a high affinity for the melanocortin-1 receptor (MC1R). By engaging this receptor, Melanotan-1 stimulates the cyclic AMP (cAMP) signaling cascade, which drives melanogenesis pathways in melanocyte cell cultures and facilitates melanin synthesis without the necessity of UV radiation. This compound is extensively used in research settings to study the biology of pigmentation, cellular signaling, and photoprotective mechanisms in dermal cell models.\u003c\/p\u003e\n\u003ch3 data-path-to-node=\"2\"\u003eProperties of Melanotan-1\u003c\/h3\u003e\n\u003cul data-path-to-node=\"3\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"3,0,0\"\u003e\u003cb data-path-to-node=\"3,0,0\" data-index-in-node=\"0\"\u003ePeptide Sequence:\u003c\/b\u003e Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"3,1,0\"\u003e\u003cb data-path-to-node=\"3,1,0\" data-index-in-node=\"0\"\u003eChemical Formula:\u003c\/b\u003e C78H111N21O19\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"3,2,0\"\u003e\u003cb data-path-to-node=\"3,2,0\" data-index-in-node=\"0\"\u003eMolecular Mass:\u003c\/b\u003e 1646.8 g\/mol\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"3,3,0\"\u003e\u003cb data-path-to-node=\"3,3,0\" data-index-in-node=\"0\"\u003eCAS Number:\u003c\/b\u003e 75921-69-6\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"3,4,0\"\u003e\u003cb data-path-to-node=\"3,4,0\" data-index-in-node=\"0\"\u003ePubChem:\u003c\/b\u003e 16154396\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"3,5,0\"\u003e\u003cb data-path-to-node=\"3,5,0\" data-index-in-node=\"0\"\u003eVial Size:\u003c\/b\u003e 3ml\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3 data-path-to-node=\"4\"\u003eLyophilized Peptides\u003c\/h3\u003e\n\u003cp data-path-to-node=\"5\"\u003eThese peptides are provided in a freeze-dried, filler-free state to maximize stability and preserve chemical integrity during storage. Reconstitute with sterile solvent immediately prior to experimental use.\u003c\/p\u003e\n\u003ch3 data-path-to-node=\"6\"\u003eDisclaimer\u003c\/h3\u003e\n\u003cp data-path-to-node=\"7\" id=\"p-rc_d35f1aabea15ef9a-20\"\u003e\u003cspan class=\"citation-35\"\u003e\u003c\/span\u003e\u003cspan class=\"citation-35 citation-36\"\u003e\u003c\/span\u003e\u003cspan class=\"citation-35 citation-36 citation-37 citation-end-37\"\u003eThis content is provided strictly for research purposes and does not constitute an endorsement or recommendation for the non-laboratory application or improper handling of peptides designed for research. The information, including discussions abou\u003csup class=\"superscript\" data-turn-source-index=\"1\"\u003e\u003c!----\u003e\u003c\/sup\u003e\u003c\/span\u003e\u003cspan class=\"citation-35 citation-36\"\u003et specific peptides and their researched benefits, is presented for informational purposes only \u003c\/span\u003e\u003cspan class=\"citation-34 citation-35 citation-36 citation-end-36\"\u003eand must not be construed as health, clinical, or l\u003csup class=\"superscript\" data-turn-source-index=\"2\"\u003e\u003c!----\u003e\u003c\/sup\u003e\u003c\/span\u003e\u003cspan class=\"citation-34 citation-35 citation-end-35\"\u003eegal guidance, nor an encouragement for non-research use in humans. \u003csup class=\"superscript\" data-turn-source-index=\"3\"\u003e\u003c!----\u003e\u003c\/sup\u003e\u003c\/span\u003e\u003cspan class=\"citation-34\"\u003e\u003c\/span\u003e\u003cspan class=\"citation-32 citation-34\"\u003e\u003c\/span\u003e\u003cspan class=\"citation-32 citation-33 citation-34 citation-end-34\"\u003ePeptides described here are solely for use in structured scientific study by authorized individuals. We advise con\u003csup class=\"superscript\" data-turn-source-index=\"4\"\u003e\u003c!----\u003e\u003c\/sup\u003e\u003c\/span\u003e\u003cspan class=\"citation-32 citation-33 citation-end-33\"\u003esulting with research experts, medical practitioners, or legal counsel prior to any decisions about obtaining\u003csup class=\"superscript\" data-turn-source-index=\"5\"\u003e\u003c!----\u003e\u003c\/sup\u003e\u003c\/span\u003e\u003cspan class=\"citation-32 citation-end-32\"\u003e or utilizing these peptid\u003csup class=\"superscript\" data-turn-source-index=\"6\"\u003e\u003c!----\u003e\u003c\/sup\u003e\u003c\/span\u003ees. \u003cspan class=\"citation-31 citation-end-31\"\u003eThe expectation of responsible, ethical utilization of this information for legitimate investigative and scholarly objectives is paramount. This notice is dynamic and governs all provided content on research \u003csup class=\"superscript\" data-turn-source-index=\"7\"\u003e\u003c!----\u003e\u003c\/sup\u003e\u003c\/span\u003epeptides.\u003c\/p\u003e\n\u003cdiv class=\"source-inline-chip-container luminous-sources ng-star-inserted\"\u003e\n\u003cbutton class=\"button multiple-button ng-star-inserted\" aria-label=\"View source details. Press Enter to open sources dialog.\"\u003e\u003c\/button\u003e\u003cbr\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"source-inline-chip-container luminous-sources ng-star-inserted\"\u003e\u003c\/div\u003e\n\u003ch3 class=\"source-inline-chip-container luminous-sources ng-star-inserted\"\u003eResearch\u003c\/h3\u003e\n\u003cp data-path-to-node=\"0\"\u003eMelanotan-1 acts as a stable alpha-MSH analog, engaging melanocortin receptors to modulate pigmentation, DNA repair, and immune regulation.\u003c\/p\u003e\n\u003cp data-path-to-node=\"1\"\u003eMelanogenesis and DNA Repair\u003c\/p\u003e\n\u003cul data-path-to-node=\"2\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"2,0,0\"\u003eMC1R binding activates cAMP-dependent cascades that upregulate tyrosinase for eumelanin production (Wang et al., 2024).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"2,1,0\"\u003eSignaling enhances nucleotide excision repair by recruiting XPA proteins to DNA damage sites, accelerating photolesion removal (Ma et al., 2021).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-path-to-node=\"3\"\u003eAnti-Inflammatory and Antioxidant Pathways\u003c\/p\u003e\n\u003cul data-path-to-node=\"4\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"4,0,0\"\u003eModulating macrophage NF-kB signaling decreases nitric oxide generation and pro-inflammatory cytokines (Polanska et al., 2024).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"4,1,0\"\u003ePI3K\/Akt\/Nrf2 pathway activation increases antioxidant enzyme expression, reducing oxidative stress (Polanska et al., 2024).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-path-to-node=\"5\"\u003eHepatic and Erythropoietic Investigations\u003c\/p\u003e\n\u003cul data-path-to-node=\"6\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"6,0,0\"\u003eMelanocortin signaling may reduce neutrophil infiltration in hepatic tissue (Polanska et al., 2024).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"6,1,0\"\u003ePeptide studies in erythropoietic protoporphyria models indicate potential for modulating protoporphyrin accumulation and erythroblast survival (Polanska et al., 2024).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-path-to-node=\"7\"\u003eReferences\u003c\/p\u003e\n\u003col start=\"1\" data-path-to-node=\"8\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"8,0,0\"\u003eMa, S. et al. (2021). Structural mechanism of calcium-mediated hormone recognition and Gbeta interaction by the human melanocortin-1 receptor. Cell Research, 31, 1269–1281. doi: 10.1038\/s41422-021-00557-y\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"8,1,0\"\u003ePolanska, A. et al. (2024). Afamelanotide in protoporphyria and other skin diseases: a review. Advances in Dermatology and Allergology, 41(3), 323-331. doi: 10.5114\/ada.2024.138818\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"8,2,0\"\u003eWang, F. et al. (2024). The biochemistry of melanogenesis: an insight into the function and mechanism of melanogenesis-related proteins. Frontiers in Molecular Biosciences, 11. doi: 10.3389\/fmolb.2024.1440187\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e","brand":"Metric Verify","offers":[{"title":"Default Title","offer_id":48604080898240,"sku":null,"price":37.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0767\/4475\/3344\/files\/melanotan_I_product_image_master_copy_1.png?v=1784007679","url":"https:\/\/metricverify.com\/products\/melanotan-1-research-peptide","provider":"Metric Verify","version":"1.0","type":"link"}